ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands

An T Vu; Alison N Campbell; Heather A Harris; Rayomand J Unwalla; Eric S Manas; Richard E Mewshaw

doi:10.1016/j.bmcl.2007.04.068

ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. doi: 10.1016/j.bmcl.2007.04.068. Epub 2007 May 4.

Authors

An T Vu¹, Alison N Campbell, Heather A Harris, Rayomand J Unwalla, Eric S Manas, Richard E Mewshaw

Affiliation

¹ Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. vua@wyeth.com

PMID: 17482813
DOI: 10.1016/j.bmcl.2007.04.068

Abstract

A new class of estrogen receptor beta (ERbeta) ligands based on the 6H-chromeno[4,3-b]quinoline scaffold has been prepared. Several C7-substituted analogues displayed high affinity and modest selectivity for ERbeta.

MeSH terms

Estrogen Receptor beta / metabolism*
Ligands
Models, Molecular
Quinolines / metabolism*

Substances

Estrogen Receptor beta
Ligands
Quinolines